Correlates of enteric vaccine induced protection

  • Organiser: Fondation Mérieux (France)

  • Venue: Conference Center les Pensières (Annecy)

  • Date: 21-23 March 2016

  • Theme: Prevention and Vaccines

The ability to assess the protective efficacy of a vaccine by measuring the proportion of vaccinees who
generate a particular immune response, without having to measure clinical outcomes, has significant
advantages. The availability and quality of such substitute endpoints are important for vaccine
development, licensure and effectiveness monitoring. A better understanding of the interrelationships
between vaccination, the immune response, protection, and clinical outcomes is thus of interest not only
to regulatory and public health authorities but also to microbiologists, immunologists, epidemiologists
and statisticians

Background

Correlates of enteric vaccine-induced protection 2016

The correlates of vaccine-induced immunity are a subject of continued interest for both theoretical and practical reasons. The latter include the need to evaluate the consistency of vaccine production; the susceptibilities of individuals and populations after vaccination; the validation of vaccines for which placebo-controlled efficacy trials are no more ethical (e.g. rotavirus vaccines), as when a priorgeneration vaccine is already licensed; and the licensure of combination vaccines.

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